Abstract
The brain is a natural target organ in hypertension and, as shown by some clinical observations, it is affected earlier than other organs and systems. Due to the specific features of the anatomy of cerebral circulation, hypertensive microangiopathy leads primarily to damage to the subcortical basal ganglia and deep white matter. Clinically, this is manifested by a concurrence of predominantly subcortical cognitive impairment and emotional and behavioral disorders as depression, emotional lability, and apathy. Some features of depression, such as the prevalence of anhedonia and fatigue and the significant severity of cognitive and somatic symptoms in an elderly person with vascular disease, suggest its organic nature (vascular depression).
Highlights
The brain is a natural target organ in hypertension and, as shown by some clinical observations, it is affected earlier than other organs and systems
Этот процесс во многом осуществляется эмоциональными механизмами, поэтому закономерным является то, что при лобной дисфункции сосудистой этиологии возможно развитие как когнитивные нарушения (КН), так и эмоциональных нарушений
В таких исследованиях, как «Аспирин в лечении бессимптомного атеросклероза» (3350 пациентов в возрасте 50–75 лет) и PRoFESS, отсутствовали различия когнитивных показателей между группами ацетилсалициловой кислоты (100 мг/сут) и плацебо, а также комбинированной терапии ацетилсалициловой кислотой с дипиридамолом медленного высвобождения [63, 64]
Summary
The brain is a natural target organ in hypertension and, as shown by some clinical observations, it is affected earlier than other organs and systems. АГ является сильным фактором риска как ОНМК, так и хронической недостаточности кровоснабжения головного мозга. Развивающаяся вследствие этого эндотелиальная дисфункция лежит в основе поражения как крупных, так мелких сосудов.
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