Abstract
Cognitive and behavioral effects of topiramate (TPM) and valproate (VPA) as adjunctive therapy with carbamazepine (CBZ) were compared in 62 adults (16 to 55 years old) with refractory partial seizures, in a randomized, double-blind trial at the Medical College of Georgia, Augusta.
Highlights
Cognitive and behavioral effects of topiramate (TPM) and valproate (VPA) as adjunctive therapy with carbamazepine (CBZ) were compared in 62 adults (16 to 55 years old) with refractory partial seizures, in a randomized, double-blind trial at the Medical
The relation between electroencephalographic (EEG) findings, behavioral, and continuous performance test indicators were examined in 23 boys, aged 9-11 years, with attention deficit hyperactivity disorder (ADHD) and 23 matched controls in a study at the State University of New York, Cortland, NY, and University of Tennessee, Knoxville, TN
The finding of increased left frontal alpha activity during reading in both normal controls and ADHD children treated with MPH (Swartwood et al 1998) may indicate inactivation of that region
Summary
The relation between electroencephalographic (EEG) findings, behavioral, and continuous performance test indicators were examined in 23 boys, aged 9-11 years, with attention deficit hyperactivity disorder (ADHD) and 23 matched controls in a study at the State University of New York, Cortland, NY, and University of Tennessee, Knoxville, TN. The EEG results showed increased alpha in posterior regions during baseline for subjects with ADHD. Boys with ADHD showed decreased alpha in the left frontal regions during reading, and increased alpha activity at T5 during a coding task. More alpha was identified at T5, T6, and 02 during the eyes open baseline condition, when compared to non-ADHD controls. Alpha persistence in the left parietal region during a coding task is indicative of parietal underactivation in ADHD. The finding of increased left frontal alpha activity during reading in both normal controls and ADHD children treated with MPH (Swartwood et al 1998) may indicate inactivation of that region. Spike-related fMRI activity was found in the left precentral gyrus, and spread to both central sulci and globus pallidi, in a 15-year-old girl with reading epilepsy. An associated localized structural abnormality caused the spikes to spread from left middle frontal working memory areas into adjacent motor cortex
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