Abstract
IntroductionCognitive deficit is a common syndrome of methamphetamine (MA) dependence. It is related to decision-making, control ability, and social functioning. High-intensity interval training (HIIT) is a training technique that requires people to work out at full intensity during a short period. Many studies have already shown the potential effects of HIIT on cognitive functions. The purpose of this trial is to evaluate the cognitive effects of HIIT on individuals with MA dependence.Methods and analysisA total of 240 individuals with MA dependence will be randomly assigned to the HIIT group, moderate-intensity continuous training (MICT) group and control (CON) group. HIIT will consist of a 24-min HIIT exercise on a treadmill. MICT will consist of a 1-h body–mind exercise. CON will be their traditional intervention. The experimental period will be 12 months with 3 interventions weekly for the first 6 months and follow-up for the next 6 months. All subjects will be given cognitive tests at baseline, after intervention and at follow-up. Cognitive performances will be compared by a mixed-model analysis for repeated measures.DiscussionHIIT training may reduce illicit drug cravings amongst individuals with MA dependence; hence, HIIT may have a good effect on the cognitive functions, such as memory and executive function, of individuals with MA dependence.Trial registrationChinese Clinical Trial Registry ChiCTR2000032492. Registered on April 30, 2020 (http://www.chictr.org.cn/edit.aspx?pid=52127&htm=4)
Highlights
Cognitive deficit is a common syndrome of methamphetamine (MA) dependence
A total of 240 individuals with MA dependence will be randomly assigned to the High-intensity interval training (HIIT) group, moderate-intensity continuous training (MICT) group and control (CON) group
HIIT training may reduce illicit drug cravings amongst individuals with MA dependence; HIIT may have a good effect on the cognitive functions, such as memory and executive function, of individuals with MA dependence
Summary
Cognitive deficit is a common syndrome of methamphetamine (MA) dependence. It is related to decision-making, control ability, and social functioning. Methamphetamine (MA) consumption has risen rapidly in the past few years with an Menglu et al Trials (2021) 22:650 mental health, social adjustment and poor mental symptoms [48, 80] These consequences may be because MA disrupts the prefrontal striatum dopamine pathway involved in various cognitive and psychomotor processes, including behavioural decision-making [55]. The most serious are related to reward or impulsiveness and social cognition [73] Such deficits are associated with decision-making disorders caused by drug addiction [70]. Another research showed that individuals with MA dependence have delayed cognition, misjudgement and poor cognitive control in the Stroop test using MArelated words as irrelevant stimuli [20] Another drawback of long-term MA use is attention deficit [7]. Individuals who are chronically exposed to illicit drugs experience difficulties in execution, inhibition and decision-making [7]
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