Abstract
We aimed to assess the association of cognitive dysfunction with health-related quality of life (HRQOL) among older adults in China. We analyzed community-based cross-sectional data of 5,557 Chinese individuals aged 60 years and above in the Weitang Geriatric Diseases Study. Cognitive dysfunction and HRQOL were assessed using the Abbreviated Mental Test (AMT) and the European Quality of Life-5 dimensions (EQ-5D), respectively. We estimated the impacts of cognitive dysfunction on the EQ-5D index and visual analogue scale (VAS) scores using linear regression models, and the association between cognitive dysfunction and self-reported EQ-5D health problems using logistic regression models. The EQ-5D index and VAS scores were significantly lower for individuals with cognitive dysfunction than their counterparts. After controlling for covariates, the differences in EQ-5D index and VAS scores between individuals with and without cognitive dysfunction were −0.016 (95% confidence interval [CI]: −0.024, −0.008), and −3.4 (95% CI: −4.5, −2.4), respectively. Cognitive dysfunction was associated with reporting of problems in pain/discomfort (odds ration [OR]: 1.37; 95% CI: 1.12, 1.69), and anxiety/depression (OR: 2.13; 95% CI: 1.41, 3.23). The negative impact on HRQOL increased with the severity of cognitive dysfunction. The results indicate cognitive dysfunction was associated with worse HRQOL in older adults.
Highlights
Two review papers had inconsistent findings: Mitchell et al suggested that cognitive impairment may affect quality of life dimensions in patients with neurological disease[14]; while Banerjee et al indicated that there is no convincing evidence of association between cognitive impairment and HRQOL in patients with dementia[15]
We aimed to investigate the relationship between cognitive dysfunction and HRQOL in a large Chinese population of noninstitutionalized older adults using multiple regression models
The relations were stronger in older person with severe cognitive dysfunction (Table 3). In this cross-sectional study of community-dwelling adults aged 60 years and above, we found that cognitive dysfunction was significantly associated with worse HRQOL
Summary
Two review papers had inconsistent findings: Mitchell et al suggested that cognitive impairment may affect quality of life dimensions in patients with neurological disease[14]; while Banerjee et al indicated that there is no convincing evidence of association between cognitive impairment and HRQOL in patients with dementia[15]. Empirical studies in both non- and institutionalized older populations have shown that the association is unlikely to be straightforward. We aimed to investigate the relationship between cognitive dysfunction and HRQOL in a large Chinese population of noninstitutionalized older adults using multiple regression models
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