Abstract
The long-term effects on cognitive functioning of school-aged children exposed to antiepileptic drugs (AEDs) in utero were investigated at Alder Hay Hospital and Walton Centre for Neurology and Neurosurgery, Liverpool, UK.
Highlights
No increase in risk of major birth defects occurred in infants of mothers exposed prenatally to lamotrigine, in reports to the International Lamotrigine Pregnancy Register (ILPR)
The risk of 2.9% with lamotrigine monotherapy was similar to that in the general population and in women exposed to other antiepileptic drugs (AEDs) monotherapy (3.3-4.5%)
With lamotrigine polytherapy including valproate, the risk increased to 12.5%; with polytherapy excluding valproate, the risk was 2.7%
Summary
No increase in risk of major birth defects occurred in infants of mothers exposed prenatally to lamotrigine, in reports to the International Lamotrigine Pregnancy Register (ILPR) The risk of 2.9% with lamotrigine monotherapy was similar to that in the general population and in women exposed to other AED monotherapy (3.3-4.5%). With lamotrigine polytherapy including valproate, the risk increased to 12.5%; with polytherapy excluding valproate, the risk was 2.7%.
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