Cognitive control, motivation and fatigue: A cognitive neuroscience perspective

Abstract

The present article provides a unified systematic account of the role of cognitive control, motivation and dopamine pathways in relation to the development of fatigue. Since cognitive fatigue is considered to be one aspect of the general control system that manages goal activity in the service of motivational requirements (Hockey, 2011), our focus is also broader than fatigue itself.The paper shall therefore first focus on the motivation-control interactions at the level of networks of the brain. A motivational control network is argued to play a critical role in shaping goal-directed behavior, in conjunction with dopamine systems that energize the network. Furthermore, motivation-control interactions as implemented in networks of the brain provide an important element to elucidate how decision making weighs both the anticipated benefits and costs of control operations, in optimal and suboptimal conditions such as mental fatigue.The paper further sketches how fatigue affects the connectivity of large-scale networks in the brain during effortful exercition, in particular the high-cost long striatal-cortical pathways, leading to a global reduction of integration in the brain’s network architecture. The resulting neural state within these networks then enters as interoceptive information to systems in the brain that perform cost-benefit calculations.Based on these notions we propose a unifying cost-benefit model, inspired by influential insights from the current neuroscience literature of how fatigue changes the motivation to perform. The model specifies how the reward value, effort costs and fatigue aspects of task performance converge in the medial prefrontal cortex to calculate the net motivation value of stimuli and select the appropriate actions.