Abstract
There is a growing recognition that the utility of the cerebellum is not limited to motor control. This review focuses on the particularly novel area of hippocampal-cerebellar interactions. Recent work has illustrated that the hippocampus and cerebellum are functionally connected in a bidirectional manner such that the cerebellum can influence hippocampal activity and vice versa. This functional connectivity has important implications for physiology, including spatial navigation and timing-dependent tasks, as well as pathophysiology, including seizures. Moving forward, an improved understanding of the critical biological underpinnings of these cognitive collaborations may improve interventions for neurological disorders such as epilepsy.
Highlights
The cerebellum has traditionally been associated with motor control, motor learning, and coordination (Glickstein, 2007; Manto et al, 2012), but it is often understood to be more broadly involved in cognitive functions as well (Strick et al, 2009; Popa et al, 2014; Taylor and Ivry, 2014)
Hippocampal-cerebellar interactions in particular may be especially relevant to temporal lobe epilepsy, as discussed later in this review
Just as the cerebellum becomes critical to hippocampal functioning on a hippocampal-dependent task when the task requires integration of self-motion cues, the hippocampus can become a vital structure in a cerebellar-dependent task
Summary
The cerebellum has traditionally been associated with motor control, motor learning, and coordination (Glickstein, 2007; Manto et al, 2012), but it is often understood to be more broadly involved in cognitive functions as well (Strick et al, 2009; Popa et al, 2014; Taylor and Ivry, 2014). This is supported in part anatomically by the marked expansion of the human cerebellum (Matano, 2001) and the connections it has developed with areas supporting cognition (Leiner et al, 1986, 1989; Weaver, 2005). Hippocampal-cerebellar interactions in particular may be especially relevant to temporal lobe epilepsy, as discussed later in this review
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