Abstract
Restless legs syndrome (RLS) is a sensorimotor disorder defined by an uncontrollable “urge to move” the limbs during rest, that is, temporarily relieved by movement and cannot be explained by other medical or behavioral conditions. 1 Allen R.P. Picchietti D.L. Garcia-Borreguero D. et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014; 15: 860-873 Crossref PubMed Scopus (738) Google Scholar Individuals with end-stage kidney disease (ESKD) are known to have a high symptom burden, 2 Murtagh F.E. Addington-Hall J. Higginson I.J. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chron Kidney Dis. 2007; 14: 82-99 Abstract Full Text Full Text PDF PubMed Scopus (569) Google Scholar , 3 Brown M.A. Collett G.K. Josland E.A. Foote C. Li Q. Brennan F.P. CKD in elderly patients managed without dialysis: survival, symptoms, and quality of life. Clin J Am Soc Neph. 2015; 10: 260-268 Crossref PubMed Scopus (129) Google Scholar , 4 Siriwardana A.N. Hoffman A.T. Brennan F.P. Li K. Brown M.A. Impact of renal supportive care on symptom burden in dialysis patients: a prospective observational cohort study. J Pain Symptom Manage. 2020; 60: 725-736 Abstract Full Text Full Text PDF PubMed Scopus (3) Google Scholar which often goes unrecognized. 5 Weisbord S.D. Fried L.F. Mor M.K. et al. Renal provider recognition of symptoms in patients on maintenance hemodialysis. Clin J Am Soc Nephrol. 2007; 2: 960-967 Crossref PubMed Scopus (181) Google Scholar Uremic RLS is reported to affect almost 30% of patients with ESKD, 6 Giannaki C.D. Hadjigeorgiou G.M. Karatzaferi C. Pantzaris M.C. Stefanidis I. Sakkas G.K. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int. 2014; 85: 1275-1282 Abstract Full Text Full Text PDF PubMed Scopus (58) Google Scholar ,7 La Manna G. Pizza F. Persici E. et al. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. Neph Dial Transpl. 2011; 26: 1976-1983 Crossref PubMed Scopus (102) Google Scholar which significantly reduces quality of life and impacts on sleep quality, ability to dialyze, 8 Winkelman J.W. Chertow G.M. Lazarus J.M. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis. 1996; 28: 372-378 Abstract Full Text PDF PubMed Scopus (334) Google Scholar and mortality. 7 La Manna G. Pizza F. Persici E. et al. Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. Neph Dial Transpl. 2011; 26: 1976-1983 Crossref PubMed Scopus (102) Google Scholar ,8 Winkelman J.W. Chertow G.M. Lazarus J.M. Restless legs syndrome in end-stage renal disease. Am J Kidney Dis. 1996; 28: 372-378 Abstract Full Text PDF PubMed Scopus (334) Google Scholar
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