Cognitive behavioral therapy may rehabilitate abnormally functional communication pattern among the triple-network in major depressive disorder: A follow-up study

Abstract

BackgroundCognitive behavioral therapy (CBT) is an established treatment for Major Depressive Disorder (MDD). MDD is characterized by imbalanced communication patterns among three networks: the central executive network (CEN), the default mode network (DMN) and the salience network (SN). The effect of CBT in restoring communications among these networks in MDD is unknown. MethodsThirty-three patients with MDD and 27 healthy controls (HC) participated in the study. Patients were treated with CBT. Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained in patients at three stages (T0: before treatment; T1: after 6 weeks CBT; T2: after 28 weeks CBT) and in HC (only T0). Both independent component analysis (ICA) and granger causality analysis (GCA) were used to explore dynamic causal communication patterns among the three networks (CEN, DMN, SN) over a course of CBT treatment. ResultsIn the HC group, the SN had an inhibitory causal effect on CEN; the CEN and DMN had an excitatory causal effect on the SN. The SN had an inhibitory causal effect on the CEN and the DMN; only the DMN had an excitatory causal effect on the SN in the MDD patients at the T0 stage. As the CBT treatment went on for MDD patients, the CEN restored excitatory causal effect on the SN, and the SN lost inhibitory effect on the DMN. This result mimicked the one found in the HC group. Four regions, left ventromedial prefrontal cortex (lvmPFC), posterior cingulate gyrus (PCC), right inferior parietal lobule (rIPL) and right insula, were implicated in mediating network communications. LimitationsThe findings should be considered preliminary given the small sample sizes, and assessed only one stage in HC subjects. ConclusionCBT may enhance the regulatory function of the SN, and rehabilitate the imbalanced brain network communication mode in the MDD. PCC, lvmPFC and rIPL may all be potential targets of CBT.