Cognitive and motor outcome in patients with early-detected central congenital hypothyroidism compared with siblings

Abstract

The results of this study are a robust argument to implement neonatal screening for central congenital hypothyroidism (CCH) worldwide. Only few countries, such as the Netherlands, screen for CCH. Neurodevelopmental outcome data are scarce for CCH compared to primary congenital hypothyroidism (PCH) not only because of the lack of widely established screening but also due to lower incidence (CCH 1:16,000 vs. PCH 1:2500-1:3000) [1].