Cognition in MS correlates with resting-state oscillatory brain activity: An explorative MEG source-space study

M.L Van Der Meer,F Barkhof,C.H Polman,P Tewarie,A Hillebrand,M.M Schoonheim,C.J Stam,L Douw

doi:10.1016/j.nicl.2013.05.003

M.L Van Der Meer, F Barkhof + Show 6 more

Open Access

https://doi.org/10.1016/j.nicl.2013.05.003

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Journal: NeuroImage: Clinical	Publication Date: Jan 1, 2013
Citations: 36	License type: cc-by

Affiliation: Amsterdam Neuroscience

Abstract

Clinical and cognitive dysfunction in Multiple Sclerosis (MS) is insufficiently explained by structural damage as identified by traditional magnetic resonance imaging (MRI) of the brain, indicating the need for reliable functional measures in MS. We investigated whether altered resting-state oscillatory power could be related to clinical and cognitive dysfunction in MS. MEG recordings were acquired using a 151-channel whole-head MEG system from 21 relapsing remitting MS patients and 17 healthy age-, gender-, and education-matched controls, using an eyes-closed no-task condition. Relative spectral power was estimated for 78 regions of interest, using an atlas-based beamforming approach, for classical frequency bands; delta, theta, alpha1, alpha2, beta and gamma. These cortical power estimates were compared between groups by means of permutation analysis and correlated with clinical disability (Expanded Disability Status Scale: EDSS), cognitive performance and MRI measures of atrophy and lesion load. Patients showed increased power in the alpha1 band and decreased power in the alpha2 band, compared to controls, mainly in occipital, parietal and temporal areas, confirmed by a lower alpha peak-frequency. Increased power in the alpha1 band was associated with worse overall cognition and especially with information processing speed. Our quantitative relative power analysis of MEG recordings showed abnormalities in oscillatory brain dynamics in MS patients in the alpha band. By applying source-space analyses, this study provides a detailed topographical view of abnormal brain activity in MS patients, especially localized to occipital areas. Interestingly, poor cognitive performance was related to high resting-state alpha1 power indicating that changes in oscillatory activity might be of value as an objective measure of disease burden in MS patients.

Highlights

Multiple Sclerosis (MS) is an acquired progressive neurological disease with a highly variable course, leading to both physical symptoms and cognitive impairment
For this purpose we reconstructed the relative power in several frequency bands for 78 atlas-based regions
We found higher mean relative power in the alpha1 band and lower mean relative power in the alpha2 band in MS patients compared to healthy controls

Summary

Introduction

Multiple Sclerosis (MS) is an acquired progressive neurological disease with a highly variable course, leading to both physical symptoms and cognitive impairment. Demyelination and axonal damage could lead to altered firing probability and to altered oscillatory cortical activity in MS. Neurophysiological techniques, such as EEG and MEG, can be used to detect such changes in activity, as has been demonstrated for neurological diseases such as Alzheimer's disease (de Haan et al, 2008; Jeong, 2004; Stam et al, 2006), Parkinson's disease (Bosboom et al, 2006; Ponsen et al, 2013; Stoffers et al, 2007), low-grade glioma (Bosma et al, 2008), traumatic brain injury (Kumar et al, 2009), and stroke (van Putten and Tavy, 2004). We hypothesize that cognitive impairment in MS patients might be partially explained by pathological changes in oscillatory brain activity

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