Year-end Sale % OFF 
Abstract
BackgroundCoffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consumption and of different brewing methods on the incidence of malignant melanoma in a prospective cohort of Norwegian women.MethodsWe had baseline information on total coffee consumption and consumption of filtered, instant, and boiled coffee from self-administered questionnaires for 104,080 women in the Norwegian Women and Cancer (NOWAC) Study. We also had follow-up information collected 6–8 years after baseline. Multiple imputation was used to deal with missing data, and multivariable Cox regression models were used to calculate hazard ratios (HR) for malignant melanoma by consumption category of total, filtered, instant, and boiled coffee.ResultsDuring 1.7 million person-years of follow-up, 762 cases of malignant melanoma were diagnosed. Compared to light consumers of filtered coffee (≤1 cup/day), we found a statistically significant inverse association with low-moderate consumption (>1–3 cups/day, HR = 0.80; 95 % confidence interval [CI] 0.66–0.98) and high-moderate consumption of filtered coffee (>3–5 cups/day, HR = 0.77; 95 % CI 0.61–0.97) and melanoma risk (ptrend = 0.02). We did not find a statistically significant association between total, instant, or boiled coffee consumption and the risk of malignant melanoma in any of the consumption categories.ConclusionsThe data from the NOWAC Study indicate that a moderate intake of filtered coffee could reduce the risk of malignant melanoma.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2586-5) contains supplementary material, which is available to authorized users.
Highlights
Coffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma
Our initial study cohort consisted of the 110,548 women who completed a version of the Norwegian Women and Cancer (NOWAC) questionnaire that included questions on both coffee consumption by brewing method and lifetime incidence of sunburn
During follow-up there was an overall decrease in coffee consumption, mainly due to a drop in boiled and filtered coffee consumption (Table 1)
Summary
Coffee contains biologically-active substances that suppress carcinogenesis in vivo, and coffee consumption has been associated with a lower risk of malignant melanoma. We studied the impact of total coffee consumption and of different brewing methods on the incidence of malignant melanoma in a prospective cohort of Norwegian women. Malignant melanoma Coffee contains caffeine, as well as potentially anticarcinogenic components such as chlorogenic acid, kahweol, and cafestol [3, 4]. Levels of these components depend on brewing method [5, 6]. Prospective studies on coffee consumption and malignant melanoma have shown conflicting results, ranging from no association [7] to a lower relative risk [8,9,10]. Recent meta-analyses of observational studies reported inverse associations, with pooled relative risks of melanoma among regular coffee drinkers compared to controls of 0.75 (95 % confidence interval [CI] 0.63–0.89) [11, 12], and 0.80 (95 % CI 0.69–0.93) [11, 12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
