Coexpression of Lyb-2 and Mac-1 by murine lymphomas and subpopulations of normal spleen and bone marrow cells.

Abstract

The earliest indication of commitment to the B lymphocyte pathway of differentiation is probably the functional rearrangement of a single immunoglobulin (Ig) heavy chain gene. The phenotypic characteristics of these B cell progenitors have not been determined, but their progeny, termed pre-B cells, are known to have rearrangements of both heavy chain genes and to express cell surface antigens Lyb-2 and Ly5(B220) (1,2). Two subpopulations of pre-B cells can be distinguished based on difference in size, rearrrangement of Ig light chain genes, and expression of the cell surface antigen, ThB. Early pre-B cells are large, have no Ig light chain rearrangements and are ThB- whereas their progeny are smaller, have rearranged at least one of their light chain genes, and are ThB+ (1).KeywordsBone Marrow CellCell Surface AntigenHeavy Chain GeneLight Chain GeneXenotropic Murine LeukemiaThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.