Abstract
The amplification of YWHAZ was commonly seen in bladder cancer. We explore the biological significance of YWHAZ amplification on bladder cancer, and the correlation with important other molecular events. The Cancer Genome Atlas (TCGA) database was exploited to study the impact of YWHAZ amplification on either CDKN2A or TP53 mutations. The Database for Annotation, Visualization and Integrated Discovery (DAVID) was also exploited to clustering of enriched genes in the cBioPortal Enrichment tests. There were 127 cases with available mutation and CNV data in the corresponding TCGA bladder cancer dataset, 20% of them had YWHAZ alteration. Patients with both YWHAZ amplification and CDKN2A loss demonstrated significantly better overall survival (OS) compared with CDKN2A loss alone. Patients with both YWHAZ amplification and TP53 mutation demonstrated significantly better overall survival (OS) and disease-free survival (DFS) compared with TP53 mutation alone. The amplification of YWHAZ, along with alteration of CDKN2A or TP53, predict better survival in bladder cancers that only had CDKN2A or TP53 alteration. The protective role of YWHAZ in bladder cancer deserve insightful further studies.
Highlights
Urinary bladder cancer remains one of the most commonly diagnosed cancers in the world
Amplification/mutation of YWHAZ was found in ~20% of cases (Figure 1)
Amplification was the predominant type of alteration for YWHAZ
Summary
Urinary bladder cancer remains one of the most commonly diagnosed cancers in the world. One strategy to improve the care of bladder cancer patients is to explore the molecular pathogenesis and novel tumor markers to predict prognosis. By integrated analysis of genomic event, we could define some subgroups of cancer type and found correlations between clinical information, which could provide robust prognosis markers. Recent report using whole-genome sequencing techniques have identified varieties of focal copy number alterations of bladder cancer, including YWHAZ, located at 8q22, a gene involved in a wide range of biological processes [4]. The link between YWHAZ and biological characteristics of bladder cancer remains poorly understood. We reported using the online analytical tools of The Cancer Genome Atlas (TCGA) database, to explore the biological significance of YWHAZ amplification on bladder cancer, and the correlation with important other molecular events
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