Abstract
Although autoimmune diseases often coexist, cases of concomitant systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare. In this paper, 20 cases of concomitant SLE and PBC in the English and Japanese literature were reviewed and summarized. In concomitant cases of SLE and PBC, PBC was diagnosed first in 68.4% (13/19) of the cases and SLE occurred first in 31.6% (6/19) of the cases, although one case was suspected to have simultaneous onset. There may be no correlation between SLE activity and PBC development. In 20 reported cases of concomitant SLE and PBC, two elderly patients died because of liver failure as a result of worsening PBC, and hepatocellular carcinoma was detected in only one elderly patient.
Highlights
No fatalities due to Systemic lupus erythematosus (SLE) were observed after administration of steroid therapy in patients with concomitant SLE and primary biliary cirrhosis (PBC)
We have summarized 20 cases of concomitant SLE and PBC
PBC was diagnosed first in 68% (13/19) of the concomitant cases and SLE occurred first in 32% (6/19), PBC was more common in middle-aged women, and SLE usually affected women of childbearing age
Summary
Systemic lupus erythematosus (SLE) is an autoimmune disease that often coexists with other collagen disorders, such as rheumatoid arthritis (RA) and Sjögren’s syndrome (SjS) [1,2]; cases of concomitant SLE and primary biliary cirrhosis (PBC) are rare [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19]. The incidence of concomitant hepatocellular carcinoma (HCC) with PBC is relatively rare, several studies have reported incidence rates of
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