Abstract
It is well known that DNA (including oligonucleotide) and cationic surfactant can form insoluble complex. In this study, by turbidity measurement and TEM image, we found that the single-chained cationic surfactant could transform the oligonucleotide/single-chained cationic surfactant precipitates into vesicles and the vesicles coexist with the insoluble complex. The hydrophobic interaction between the cationic surfactant and the precipitates plays a key role in vesicle formation. Moreover, when the temperature reaches a specific value where the oligonucleotide begins to melt, the oligonucleotide/single-chained cationic surfactant vesicles form far easier. Thus, the more extended the oligonucleotide, the much easier for vesicle formation. As far as we know, the study about the oligonucleotide/cationic surfactant vesicle formation is very limited. Therefore, considering the growing importance and significance of DNA (including oligonucleotide)/amphiphile systems in medicine, biology, pharmaceutics, and chemistry, this study should provide some helpful information in further understanding these systems.
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