Abstract
Coexistence of MCH- and α-MSH-like peptides in specific neurons of the frog hypothalamus has been investigated on serial frozen sections using the indirect immunofluoreseence method. In the anterior region of the preoptic nucleus, perikarya containing MCH- and a-MSH-immunoreactive materials were co-distributed and the two peptides were generally co-sequestered within the same neurons. In contrast, α-MSH immunoreactive neurons of the ventral infandibular nucleus did not contain any MCH-like peptide. These data suggest that MCH and α-MSH are transported by the same nerve fibers originating from preoptic perikarya and are likely released together by axon terminals. Since MCH and α-MSH exert antagonistic hormonal activities on dermal melanophores, our results suggest that the two regulatory peptides may also interact in the central nervous system.
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