CO-EXISTENCE OF HELICOBACTER PYLORI IN GASTRIC AND GALLBLADDER MUCOSA IN CHOLECYSTITIS PATIENTS: A CROSS-SECTIONAL STUDY

Abstract

This study was designed to assess the frequency of co-existence of H. Pylori in gastric and gallbladder mucosa of patients with acute cholecystitis or who had symptoms of cholelithiasis. This cross-sectional analysis was conducted at Bahria Town International Hospital Lahore from September 2020 to September 2021. The study consisted of 51 participants, all diagnosed with either acute cholecystitis or symptomatic cholelithiasis. Information regarding the patients' ages, genders, and the H. pylori existence in the mucosa of their gastric and gallbladders was collected and analyzed with SPSS version 22. H. pylori was discovered in the gallbladder mucosa of 22 individuals, which accounts for 43.1% of all cases, and in the gastric mucosa of 16 patients, which accounts for 31.1% of all cases. The co-existence of H. pylori in both the mucosa of the gallbladder and gastric wall was found in six (11.8%) patients. The co-existence of H pylori was significantly greater in patients with acute cholecystitis compared to those with cholelithiasis (p = 0.021). This study showed no significant relationship between age and smoking history with the co-existence of H. pylori in gastric and gallbladder mucosa. The findings of this study indicate that the presence of H. pylori infection is extensive in the gallbladder and stomach mucosa of the patients diagnosed with acute cholecystitis and cholelithiasis. When evaluating patients with gallbladder issues, it should be considered the presence of H. pylori in both the gallbladder and gastric mucosa.