Coexistence D’un Lymphome Lymphocytique Et D’une Leucémie Myéloïde Chronique: A Propos De Deux Observations Au Togo

Abstract

This paper reported two cases of lymphocytic lymphoma associated with chronic myeloid leukemia (CML) in Togo. The first association is a simultaneous coexistence of a CML with the presence of the transcript bcr-abl, in a 32-year-old woman, at chronic myelocytic stage with polyadenopathy required and lymph node biopsy concluded for lymphocytic lymphoma. The second is the case of a 30-year-old man who developed a lymphocytic lymphoma after 6years and 5 months of following CML. These two cases are comparable to other associations of acute or chronic myeloid and lymphoid blood malignancies that was previously published. Several pathogenic hypothesis were reviewed which takes responsibility for chemotherapy. Nevertheless, the diagnosis is sometimes simultaneous with the involvement of cellular oncogenes. This is a more likely clonal abnormality of the stem cell sequentially or concomitantly expressed in the cells on both lineages. To the best of our knowledge, these are the first descriptions in South-Saharan Africa.