Abstract
Objective: This study had been designed to evaluate the effects of Coenzyme Q10 (CoQ10) supplementation on the lipid ratios in women with type 2 diabetes mellitus (T2DM).
 Materials and Methods: Sixty-eight women with T2DM were enrolled and randomly divided into two groups. While one group received 100 mg/day of CoQ10 supplement for 12 weeks (n=34) the other was given placebo for the same time duration (n=34). Lipid profile including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were evaluated at the beginning and at the end of the intervention and lipid ratios were calculated.
 Results and Discussion: After the intervention, values of non-HDL-C (p=0.001), TG/HDL-C (p=0.03) and LDL-C/HDL-C (p=0.001) were significantly decreased in CoQ10 group. Values of HDL ratio (p=0.002) were increased significantly in CoQ10 group.
 Conclusion: This study showed that daily supplementation with 100 mg of CoQ10 in women with T2DM could improve some atherogenic lipid ratios that might be useful in preventing cardiovascular diseases in them.
 Bangladesh Journal of Medical Science Vol.19(1) 2020 p.152-158
Highlights
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia which is associated with impaired metabolism of carbohydrates, lipids, and proteins that can result from defects in insulin secretion or insulin action [1, 2]
Of 80 women with type 2 diabetes mellitus (T2DM) who were enrolled in the current study, 68 patients completed the 12-weeks intervention while 12 patients did not respond to the follow-up because of not meeting inclusion criteria and unwillingness to cooperate in the intervention (Figure 1)
Comparison between two groups showed that the reduction of the total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio and low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio were statistically significant in Coenzyme Q10 (CoQ10) group compared to the placebo (3.59±0.10 vs. 4.23±0.13, p
Summary
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia which is associated with impaired metabolism of carbohydrates, lipids, and proteins that can result from defects in insulin secretion or insulin action [1, 2]. Coenzyme Q10 supplementation effects on lipid ratios in women with type 2 diabetes mellitus: A randomized, double-blind clinical trial study resistance plays an important role in the development of is 12. The current study was designed to evaluate the effects of CoQ10 supplementation on the lipid ratios in women with T2DM.
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