Abstract
Skin is the largest barrier protecting from environmental risk factors that can result in skin aging. Skin aging can be categorized...
Highlights
Skin is the largest barrier protecting from environmental risk factors that can result in skin aging
The results showed that liver weight was significantly decreased when the mice were exposed to ultraviolet B radiation (UVB) compared to control mice (Figure 1)
The heart weight was not affected by Coenzyme Q10 (CoQ10) and Titanium dioxide (TiO2) sunscreen compared with control mice (Figure. 1)
Summary
Skin is the largest barrier protecting from environmental risk factors that can result in skin aging. Skin aging can be categorized into intrinsic and extrinsic responses. The intrinsic skin aging occurs naturally as time passes [1], while extrinsic factors in skin aging are related with infection, water loss, and ultraviolet ray [2]. Eventhough only 5% of ultraviolet B radiation (UVB) light reaches the upper dermis of the skin, it is a key risk factor of extrinsic skin aging that affects dermal fibroblasts and skin microenvironment [3]. A major component of extracellular matrix (ECM), is associated with extrinsic skin aging. Since wrinkle formation is evidenced by collagen degradation, the attenuation of MMP-1 activity is an important method for preventing skin aging [6,7].
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