Coenzyme-Q10 deficiency and stress oxidative in children with autism spectrum disorders.

Abstract

We assume that serum concentration of total CoQ10 and stress oxidative factors could be used as important biomarkers of therapy. Sixty children (aged 3-12 years), one group consisted of children with autism (n=30) and other consisted of health children (n=30). Children with autism according to the DSM-IV criteria and using CARS were included in the study. All the subjects were Iranian, born and living in the state Khuzestan. This was an original study. The present study aimed to analyze the serum levels of concentration of CoQ10−TOTAL, in the children. In total, patient group and health group, including boys and girls, were matched for age, gender, and body mass index (BMI). Serum levels of CoQ10−TOTAL in children with ASDs were significantly lower than that in the healthy children. We propose that serum concentration of CoQ10−TOTAL could be used as relevant biomarkers of CoQ10 supportive therapy. Overall supplementation with Co-Q1 provide promising alternatives to current therapies for neurodevelopmental disorders. CoQ10 is a naturally occurring flavonoid with potent antioxidant, properties that are found in green plants. This study with a larger number of patients is confirmed this previous research.