Coenzyme Q10 – a literature review on supplementation in chronic disorders and the anti-aging process

Abstract

Introduction: The continuous growth and aging of the population poses enormous challenges in maintaining the health of the entire world’s population, which is forecasted to exceed 9 billion by 2050. Diseases of the XXI century can be prevented by reducing risk factors and appropriate prophylaxis, which also includes supplementation. Aim: The aim of the study was to summarise data on the effects of coenzyme Q10 on the course of chronic diseases and the aging process. Materials and methods: PubMed and Google Scholar databases were searched. Most of the articles published after 2012 were reviewed. Brief description of the state of knowledge: Decreased levels of coenzyme Q10 and increased levels of oxidative stress have been found in the course of multiple chronic diseases. It seems logical that coenzyme Q10 supplementation improves mitochondrial function and provides antioxidant protection to organs and tissues affected by various pathophysiological conditions. In addition to significantly improving cardiovascular and neurological functions, coenzyme Q10 has also found a wide application in delaying skin aging processes. Conclusions: Coenzyme Q10 is the third most commonly used dietary supplement in the world. The efficacy of coenzyme Q10 in selected groups of patients has been confirmed in clinical trials. More research and clinical trials are needed with more participants undergoing longer-term supplementation to assess the benefits of coenzyme Q10.