Abstract
Objective To clarify a potential therapeutic role of coenzyme Q 10 (CoQ 10) in infertile men with idiopathic asthenozoospermia. Design Open, uncontrolled pilot study. Patient(s) Infertile men with idiopathic asthenozoospermia. Intervention(s) CoQ 10 was administered orally; semen samples were collected at baseline and after 6 months of therapy. Main outcome measure(s) Semen kinetic parameters, including computer-assisted sperm data and CoQ 10 and phosphatidylcholine levels. Result(s) CoQ 10 levels increased significantly in seminal plasma and in sperm cells after treatment. Phosphatidylcholine levels also increased. A significant increase was also found in sperm cell motility as confirmed by computer-assisted analysis. A positive dependence (using the Cramer's index of association) was evident among the relative variations, baseline and after treatment, of seminal plasma or intracellular CoQ 10 content and computer-determined kinetic parameters. Conclusion(s) The exogenous administration of CoQ 10 may play a positive role in the treatment of asthenozoospermia. This is probably the result of its role in mitochondrial bioenergetics and its antioxidant properties.
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