Abstract
A supercritical fluid-based method is proposed to produce coenzyme Q 10 (CoQ 10) nanoparticles. First, CoQ 10/polyethylene glycol 6000 composite particles are prepared by a modified PGSS (particles from gas-saturated solutions) process with controlling the flow rate of the gas-saturated solution. Then, CoQ 10 nanoparticles are obtained by dissolving the composite particles into water. The effect of experimental variables of the modified PGSS process, including pressure, temperature, flow rate of the gas-saturated solution, and mass fraction of CoQ 10, on the CoQ 10 particle size and particle size distribution was investigated. Results show that CoQ 10 slurry product with a median diameter of 190 nm and yield of 89.8% can be prepared at an optimum condition (operating pressure of 25 MPa, operating temperature of 80 °C, gas-saturated solution flow rate of 1.02 mL/min, CoQ 10 mass fraction of 40% and nozzle diameter of 100 μm) via the supercritical fluid-based method.
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