Abstract
Codonopsis lanceolata extract (CLE) has been used in traditional medicine in the Asian-Pacific region for the treatment of bronchitis, cough, and inflammation. However, it is still unclear whether obesity in mice can be altered by diet supplementation with CLE. To investigate whether CLE could have preventative effects on high fat diet (HFD)-induced obesity, male C57BL/6 mice were placed on either a normal chow diet, 60% HFD, or a HFD supplemented with CLE (60, 180, and 360 mg/kg/day) for 12 weeks. CLE decreased body weight and subcutaneous and visceral fat weights in HFD-induced obese mice. CLE group mice showed lower fat accumulation and a smaller adipocyte area in the adipose tissue compared with the HFD group mice. CLE group mice exhibited lower serum levels of triglycerides, total cholesterol, low density lipoprotein (LDL), glucose, and insulin compared with the HFD group mice. In addition, CLE decreased liver weight and lowered the increase in aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in HFD-induced obese mice. These results indicate that CLE can inhibit the development of diet-induced obesity and hyperlipidemia in C57BL/6 mice.
Highlights
Obesity has recently emerged as a major health problem and risk factor for various disorders worldwide [1,2]
To evaluate the preventative effects of Codonopsis lanceolata extract (CLE) on high fat diet (HFD)-induced obesity, we investigated the development of HFD-induced obesity in C57BL/6 mice with and without CLE supplementation for
These results suggest that the HFD resulted in obesity, but the administration of CLE suppressed body weight gain and excess fat accumulation in adipose tissue in HFD-fed C57BL/6 mice
Summary
Obesity has recently emerged as a major health problem and risk factor for various disorders worldwide [1,2]. Known as sibutramine, is approved for long-term use with diet and exercise as an appetite suppressant for the treatment of obesity; patients often experience eventual weight regain and side effects [7,8]. This tendency has led to an increase in the consumption of functional foods for obesity prevention, leading to a strong demand for the development of new sources of functional foods and related studies on their efficacy [9,10,11].
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