Abstract
Aspirin is the first non-steroidal drug used clinically in humans with a wide range of pharmacological effects [1]...
Highlights
Aspirin is the first non-steroidal drug used clinically in humans with a wide range of pharmacological effects [1]
We investigated the effect of Codonopsis decoction on aspirininduced gastric damage both in vivo and in vitro
Aspirin-induced the low levels of COX-1, COX-2 and transforming growth factor-α (TGF-α) in GES-1 culture supernatant were significantly attenuated by Codonopsis decoction at all doses
Summary
Aspirin is the first non-steroidal drug used clinically in humans with a wide range of pharmacological effects [1]. Because aspirin has the effect of anti-thrombosis in the body, it is widely used in the treatment of cardiovascular and cerebrovascular diseases [2,3]. Long-term use of aspirin in the process of treating cardiovascular and cerebrovascular diseases can cause gastric mucosal damage, gastrointestinal dysfunction, and eventually show side effects such as nausea, vomiting and gastrointestinal bleeding [4]. TGF-α and COX are important molecules for gastric tissue damage repair. COX-1 is a physiological enzyme that catalyzes the synthesis of prostaglandin (PG) involved in normal physiological functions, and maintains the integrity of the gastrointestinal mucosa [6]. As important inflammatory cytokines TNF-α and IL6, which participate in the process of gastric mucosal damage [9]
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