Abstract
Glucocorticoids and dopamine (DA) may affect brain development and permanently programme central nervous system (CNS) responses. The ontogeny of the striatal glucocorticoid receptor (GR) mRNA and of DA D 1, D 2 and D 3 receptor subtype mRNAs were, therefore, studied by means of in situ hybridization techniques. The expression of GR and the dopamine D 3 receptor mRNAs but not of DA D 1 and D 2 receptor subtype mRNAs were observed in the striatal neuroepithelium during all prenatal stages studied (E14.5–E20.5). These results suggest that GR may directly influence striatal developmental processes, possibly involving the dopamine D 3 receptor.
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