Abstract
Gene expression data for duplicated gene pairs in humans provides insights into the regulatory factors affecting the expression divergence of these genes and implications for their evolution.
Highlights
Gene expression divergence is one manifestation of functional differences between duplicate genes
Katju and Lynch [15] demonstrated that more than half of newborn duplicate genes in Caenorhabditis elegans represent not complete, but rather partial or chimeric duplications. Such structural heterogeneity may play an important role in rapid expression divergence between human duplicate genes as well; it has not been considered in detail in previous studies
Identification of duplicate genes Utilizing two different methods, FASTA and TRIBE-MCL, we identified 6,536 and 7,027 non-redundant human duplicate gene pairs, respectively
Summary
Gene expression divergence is one manifestation of functional differences between duplicate genes. Genome Biology 2009, Volume 10, Issue 1, Article R10 Park and Makova R10.2 models have been implemented under the assumption that two duplicated gene copies are structurally and functionally identical immediately after duplication. Katju and Lynch [15] demonstrated that more than half of newborn duplicate genes in Caenorhabditis elegans represent not complete, but rather partial or chimeric duplications Such structural heterogeneity may play an important role in rapid expression divergence between human duplicate genes as well; it has not been considered in detail in previous studies
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