Abstract
The active moiety with poor solubility is posing a challenge in drug development which may reduce the effectiveness in patients when administered orally. Cocrystal formation is one of the latest approaches for improving the various parameters of a drug molecule such as solubility, melting point, pharmacokinetic, pharmacodynamic, and bioavailability. Cocrystals are crystalline single state materials composed of two or more than two different molecular amalgams held together in a fixed stoichiometric ratio. There are various techniques used for the preparation of cocrystals such as solvent evaporation, grinding, and cooling crystallization. The quantitative and qualitative aspects of these cocrystals are evaluated using various validated instruments such as nuclear magnetic resonance, powder X-ray diffraction, and differential scanning calorimetry.
Highlights
Cocrystal concept of the supramolecular chemistry is gaining wide interest of researchers from pharmaceutical, chemical sciences, and regulatory agencies
Pharmaceutical cocrystal engineering has emerged as a new era in the field of medicine in developing a new moiety with improved solubility, dissolution, bioavailability, micrometric properties, and pharmacokinetic and pharmacodynamic properties of a drug
Pharmaceutical cocrystals are described as crystalline single state materials composed of two or more than two different molecular amalgams held together in a fixed stoichiometric ratio
Summary
Cocrystal concept of the supramolecular chemistry is gaining wide interest of researchers from pharmaceutical, chemical sciences, and regulatory agencies. API and coformer are melted and mixed together, resulting in the cocrystal formation in a fixed stoichiometric ratio. Dry grinding method It is most widely and commonly used technique for cocrystal formation, in which API and coformers are mingled in a stoichiometric proportion using mortar and pestle.
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