Cocrystallization-driven self-assembly with vanillic acid offers a new opportunity for surmounting fast and excessive absorption issues of antifungal drug 5-fluorocytosine: a combined theoretical and experimental research

Abstract

The cocrystal of 5-fluorocytosine (FCY) with vanillic acid (VAA) was assembled via a cocrystallization technique, giving a novel understanding for conquering the dose-limited hepatotoxicity caused by the rapid and almost complete absorption of FCY.