Abstract
Our lab has previously demonstrated the ability of German cockroach allergens (CRA) to induce allergic‐type airways inflammation in BALB/c mice. This model resembles human allergic asthma in its histology, symptomatology and airways hyperreactivity. We reproduced this model in outbred (ICR) mice to extend our observations and establish a more applicable model to the extremely outbred human population. Mice were given 4.75ug, 2.4ug and 2.4ug of CRA intratracheally on days 0, 14, and 21. Airways hyperresponsiveness (AHR) and cell content of bronchoalveolar lavage fluid was measured 24 hours post final challenge and the results compared to BALB/c mice.Because of the encouraging data this model has produced, and the greater applicability of its genetically diverse background, we believe outbred animal experiments are highly appropriate in simulating human disease.
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