Abstract
Serial propagation of avian coccidia in birds fed mash containing coccidiostats results in the acquisition of a resistance for the specific coccidiostat. This is stable and persists virtually unchanged when the resistant strains are passed serially through groups of unmedicated chickens. When passed through groups of chickens fed mash containing a different coccidiostat, some strains, in addition to acquiring a tolerance for the second chemical, regained their sensitivity to the first, while others did not and were now resistant to two compounds. Although acriflavine did not influence the development of amprolium resistance by a strain of Eimeria tenella, serial exposure of an amprolium-resistant strain to this chemical mediated a reversion to the sensitive state. Attempts to demonstrate transmissible drug resistance among coccidia were unsuccessful.
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