Abstract
Introduction Elevated myocardial triglyceride levels have been observed within the myocardium of diabetic and obese individuals. Use of cocaine leads to cardiomyopathy and precipitation of cardiovascular disease such as myocardial infarction, ventricular arrhythmias, and left ventricular dysfunction. Proton magnetic resonance spectroscopy (1H-MRS) has been applied to measure lipid overload in the human heart [1].
Highlights
Elevated myocardial triglyceride levels have been observed within the myocardium of diabetic and obese individuals
The prevalence of cardiac steatosis in cocaine users was significantly higher than that in those who did not use cocaine (65.7% in cocaine users, and 16.7% in cocaine non-users, p < 0.004)
Exact logistic regression analysis indicated that after controlling for age, gender, glucose, triglycerides, and systolic blood pressure, cocaine use was associated with a 14-fold risk of cardiac steatosis
Summary
Elevated myocardial triglyceride levels have been observed within the myocardium of diabetic and obese individuals. Use of cocaine leads to cardiomyopathy and precipitation of cardiovascular disease such as myocardial infarction, ventricular arrhythmias, and left ventricular dysfunction. Proton magnetic resonance spectroscopy (1H-MRS) has been applied to measure lipid overload in the human heart [1]. The primary goal of the present study was to evaluate the myocardial fat in cocaine abusers. We applied 1H-MRS to quantify myocardial septal triglyceride content compared to the non-cocaine users to ascertain the prevalence and severity of cardiac steatosis among cocaine-use patients. Fat content was quantified with Amares/MRUI and related to water in unsuppressed spectra and expressed as fat/ water percent ratios
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