Abstract
Cocaine induced midline destructive lesions
Highlights
In our case series we have developed a multidisciplinary pathway for patients presenting with nasal destructive changes and a prior history of cocaine use
Anti-neutrophil cytoplasmic antibodies (ANCA) offer a diagnostic aid when considering a diagnosis of granulomatous vasculitis conditions but as highlighted in our paper 56% of patients with CIMDL’s are c-ANCA positive with high levels of MPO antibodies
A negative result in this regard should be reviewed with caution given the time for seroconversion with some patients with a true granulomatous vasculitis having negative results in early stages of the disease
Summary
In our case series we have developed a multidisciplinary pathway for patients presenting with nasal destructive changes and a prior history of cocaine use. Throughout the diagnostic process there are clues that can guide clinicians as to the presence of systemic involvement.
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