Abstract
The first part of this review describes the pharmacology of cocaine, followed by a short summary of the metabolism, storage, and release of norepinephrine. The remainder discusses possible interactions between cocaine and drugs whose main effector site is the adrenergic neurone. The following medications are mentioned: methyldopa, imipramine, chlorpromazine, monamine oxidase inhibitors, guanethidine, reserpine, phentolamine hydrochloride, propranolol, and epinephrine. The mechanism of drug reactions which may give rise to hypertensive crises and may be responsible for serious complications or death in patients undergoing minor surgery under local anesthesia are described. Knowledge of these interactions will be helpful in preventing serious mishaps.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
