Abstract
Rats receiving an injection of cobalt (Co) showed marked changes in plasma kininogen (Brady kininogen, BKG) levels, and alterations in arginine-esterase and bradykininase activity. A significant increase in BKG concentrations was seen at 4 and 24 hr after Co treatment, with maximum titers occurring 4 hr after treatment. Plasma kallikrein activity was significantly increased between 1 and 24 hr after Co treatment. Co initiated a decrease in plasma kininase activity, with minimum activity occurring 8 hr after treatment. Plasma protease showed peak activity approximately 8 hr after Co administration. However, Co added in vitro failed to enhance the proteolytic activity of rat plasma from normal as well as cobalt-treated rats. Plasma protein concentrations were significantly increased above control levels at 18 and 24 hr after cobalt treatment. These observations would seem to suggest that Co. which is known to initiate a state of histotoxic (tissue) hypoxia, might be triggering a mechanism(s) responsible for the changes seen in the plasma.
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