Abstract
The cobalt(II) ion-promoted hydrolysis of the widely used cephalosporin antibiotic cephalexin is confirmed by solid crystallographic characterization of the cephalosporoate–cobalt(II) complex [Co(cephalosporoate) 2] · 6H 2O ( 1), obtained from an aqueous solution containing Co(OAc) 2 and cephalexin. The crystal structure analysis results prove that the double bond of dihydrothiazine ring in cephalosporoate undergoes a shift from position 3–4 to 4–5 in aqueous media at low pH, with the consequent uptake of a proton at C(3) by the α face.
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