Abstract
AbstractThe first example of CoCl2‐catalyzed formal [5+2] oxidative annulation of o‐arylanilines with alkynes was developed, giving access to various important imine‐containing dibenzo‐[b,d]azepine scaffolds through sequential C−C/C−N bond formation. The reaction employs catalytic amount of manganese and oxygen as cooxidants, and features a broad substrate scope. Preliminary mechanistic studies suggested that C−H activation is involved in the rate‐determining step. Moreover, both internal and terminal alkynes are well tolerated in this transformation. Besides, a regioselective migratory insertion was observed when using terminal alkynes as substrates.magnified image
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