Cobalt Compensator-Based IMRT for Gynecologic Cancer Treatment in Low- and Middle-Income Countries: Equivalence to LINAC-Based IMRT

Abstract

Cobalt intensity modulated radiation therapy (IMRT) has the potential to impact global oncology by improving access to precision radiation therapy, particularly in low- and middle-income countries, and a novel compensator-based machine has been developed. Previously, cobalt compensator-based IMRT and LINAC-based IMRT were shown to achieve similar target goals and dose constraints for head and neck clinical cases. Additionally, the fidelity of those calculations was supported by Monte Carlo simulations and gamma analysis. The current study investigates the use of cobalt compensator IMRT for another application - gynecologic cancer patients. A commercial treatment planning system was previously commissioned for the cobalt compensator-based device using Monte Carlo simulations from a simulation toolkit. Patient-specific compensators were modeled. Clinical gynecologic cancer cases were planned and compared to clinical plans with a 6MV LINAC using IMRT. The prescribed dose was 45 Gy in 25 fractions. Dosimetric plan quality endpoints for the planning target volume (PTV) and organs-at-risk (OARs) were compared. Parametric t-testing was used for statistical analysis, and criteria for significance was p<0.05. Dose statistics of 10 cases showed similar target coverage and normal tissue sparing between IMRT plans using a 6 MV LINAC and using a cobalt compensator-based device. Greater than 95% of the dose to greater than 95% of the PTV was achieved for all 10 cases using both the LINAC-based and cobalt compensator-based plans. There was no significant difference in the mean percentage of the PTV receiving 95% of the dose between LINAC-based and cobalt compensator-based plans (98.0 ± 1.88% vs 97.1 ± 1.90%, respectively, p = 0.313). Additionally, both the LINAC-based and cobalt compensator-based plans, for all 10 cases, met dose constraints for the OARs, including Spinal Cord Dmax < 4500 cGy, Kidney Dmean < 1800 cGy, Bladder Dmax < 5750 cGy, Rectum Dmax < 5500 cGy, Small Bowel Dmax < 5400 cGy, Bone Marrow V4000 < 37%, and Femoral Heads Dmax < 5000 cGy. Cobalt compensator-based IMRT may provide comparable quality treatment plans to LINAC-based IMRT for gynecologic cancer patients. Physical development of the cobalt compensator device has been completed and will be commissioned for further research to assess clinical outcomes.