Abstract
AbstractA cobalt‐catalyzed regioselective [4+2] annulation/lactonization reaction of benzamides with 4‐hydroxy‐2‐alkynoates is reported. This reaction utilizes air as an oxidant rather than metal salts. The method is operationally simple, mild, and sustainable. This protocol exhibits a broad substrate scope and compatible with a variety of functional groups furnishing the corresponding 1,4‐dihydrofuro[3,4‐c]isoquinoline‐3,5‐dione derivatives in good to excellent yields with high regioselectivity.magnified image
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