Cobalt-catalyzed O-arylation of N-protected amino alcohols with arenes via cross-dehydrogenative C-O coupling strategy: Direct access to aryloxyamines

Abstract

An efficient Co(II)-catalyzed cross-dehydrogenative C-O coupling strategy for the arylation of N-protected amino alcohols, including 1,2-, 1,3- and 1,4-amino alcohols, branched amino alcohols and cyclic amino alcohols with different amides derivatives has been developed, affording a wide range of corresponding aryloxyamines compounds with excellent convertibility in moderate to good yields, which are of great interest in medicinal and pharmaceutical chemistry. Furthermore, this reaction system could be further applied to the preparation of potential bioactive molecules.