Abstract
Ultrasound-modulated optical spectroscopy within a coaxial system capable of attaining submillimeter spatial resolution has been developed to investigate scattering media spectroscopic properties at depths of several centimeters. By using stroboscopic illumination methods, a broad spectral bandwidth pulsed laser and a focused ultrasound pulse simultaneously irradiated a biological tissue phantom containing oxyhemoglobin and deoxyhemoglobin absorbers. The ultrasound-modulated optical spectroscopic images were synchronously acquired by a fiber optic spectrometer scanning in two dimensions. We have obtained the wavelength dependent ultrasound-modulated optical signals produced by the ultrasound interactions changing the distribution of scattered light through several different mechanisms and evaluated the proposed system.
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