Abstract
While platelets are acknowledged as critical components of ischemic stroke pathophysiology, little is known about the role of platelet reactivity or platelet subclasses in stroke. Coated-platelets are a pro-thrombotic subclass of platelets, levels of which can vary substantially among individuals. Recently, coated-platelets were observed to be elevated in cortical stroke patients and decreased in lacunar stroke patients, thereby providing for the first time a biochemical marker distinguishing these two stroke subtypes. This article reviews the primary observation as well as the clinical and epidemiological implications of this finding.
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