Abstract
This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71±0.51; 1.96±0.87; 2.84±0.22 Units/mg protein respectively) and catalase (4.10±0.10; 8.25±1.24; 6.28±0.11 Units/mg protein respectively) activities were significantly (p<0.05) elevated in "parasitized and treated" (PnT) animals. Renal glutathione level (19.02±0.20μg/mL) was elevated in PnT animals. Glutathione S-transferase and malondialdehyde levels in hepatic (8.76±0.49μmol/min/mg; 527.23±24.56mmol/dL) and renal (3.35±0.30μmol/min/mg; 464.42±59.13mmol/dL) tissues were significantly high (p<0.05) in coartemether-treated animals alone. Plasma aspartate transferase (9.45±3.59 U/L) and alanine transferase (5.78±2.36 U/L) were high in PnT animals. Therefore, data indicates that in the presence of P. berghei, coartemether could alter the antioxidant status and induce hepatotoxic damage in mice.
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