Abstract
Colistin is a potent polycationic polymyxin antibiotic that sees wide use topically for multidrug resistant Gram-negative bacteria. Its ability to break down the membrane is a double edged sword due to the non-selective nature of its mode of action. Ingestible colistin is a last resort against severe infections, but recent experimental work has shown there promise when it is injected in nanoparticle form with other constituents. Compared with free colisitin, the nanoparticle showed either retained or enhanced efficacy and a lower hepatotoxicity in mice. This work explores the coarse-grained dynamics of this system and its mode of action with model bacterial membranes, as well as the structure of the amorphous nanoparticle coacervate.
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