COAP/Pd-catalyzed asymmetric linear allylic alkylation for synthesizing chiral 3,3′-disubstituted oxindoles bearing all-carbon quaternary stereocenters and primary allylic alcohol structures

Abstract

A linear asymmetric allylic alkylation of vinyloxirane catalyzed by a chiral oxalamide–phosphine (COAP)/Pd(0) complex was reported. Various chiral 3,3′-oxindole derivatives were achieved in good yields with excellent regio- and enantioselectivity.