Abstract
Cells grown in vitro are inhibited to a greater extent by leachates of coal particles from a mine in Pennsylvania where the miners have a high incidence of Coal Workers' Pneumoconiosis than by leachates of coal of the same particle size but from a mine in Utah where the miners show a low prevalence of the disease. Leachates of respirable particles (1.5 μm and less) of the two coals caused markedly different responses in the cell culture system. The leachate from the Pennsylvania coal caused a growth depression while chemicals leached from the same size particles of the Utah coal stimulated cell growth. The concentration of selected metals in the leachates of the two coal samples differed. The results support the hypothesis that toxic substances leached from coal may be a factor in the etiology of CWP.
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