Abstract
Recently, coronavirus disease 2019 (COVID-19) has been considered as a major health problem around the globe. This severe acute respiratory syndrome has a bunch of features, such as high transmission rate, which are adding to its importance. Overcoming this disease relies on a complete understanding of the viral structure, receptors, at-risk cells or tissues, and pathogenesis. Currently, researches have shown that besides the lack of a proper anti-viral therapeutic method, complications provided by this virus are also standing in the way of decreasing its mortality rate. One of these complications is believed to be a hematologic manifestation. Commonly, three kinds of coagulopathies are detected in COVID-19 patients: disseminated intravascular coagulation (DIC), pulmonary embolism (PE), and deep vein thrombosis (DVT). In this paper, we have reviewed the relation between these conditions and coronavirus-related diseases pathogenesis, severity, and mortality rate.
Highlights
During the past two decades, members of coronaviridae family have caused severe global economic and health problems on a large scale
Three species of coronaviruses called SARS-CoV-1, Middle East Respiratory Syndrome (MERS), and SARS-CoV-2 are responsible for three outbreaks which occurred in 2002, 2012, and 2019, respectively.[1,2,3]
Léonard-Lorant and colleagues reported that 30% of the COVID-19 patients enrolled in their study were diagnosed with acute pulmonary embolism.[40]
Summary
During the past two decades, members of coronaviridae family have caused severe global economic and health problems on a large scale. The importance of these diseases is related to the respiratory disturbance, the number of deaths, or the high transmission rate of these viruses.[2] The fact that other organs of our body such as brain, heart, and kidneys are prone to be affected by coronaviruses is making the process of treatment more complicated and the disease prognosis poorer In this regard, cardiovascular, metabolic, renal, and nervous system disorders have been observed in patients infected with coronaviruses.[4,5,6,7,8,9] Currently, the association of these viruses has been reported with a lifethreatening condition: coagulopathy.[10]. This paper might be a great help for facilitating the treatment process, decreasing the mortality rate, and increasing the life quality of CoV-related diseases
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