Abstract
Coagulation activity increases, and fibrinolysis activity decreases in exudative pleural effusion. The blood coagulation factors increase in the former, and plasminogen activator inhibitors increase in the latter. This coagulation-fibrinolysis imbalance may cause fibrin deposition, resulting in pleural fibrosis. Inflammatory cytokines can induce coagulation-fibrinolysis imbalance, which also affect the inflammatory process. There is no inflammatory response and coagulation-fibrinolysis imbalance in transudative pleural effusion, which rarely causes pleural fibrosis. Key words: Pleural effusion; Coagulation; Fibrinolysis; Inflammation
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